| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NADPH oxidase 4 |
|---|
| Ligand | BDBM318936 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Nox4 Assay |
|---|
| IC50 | 1680±n/a nM |
|---|
| Citation |  Wikström, P; Walum, E; Wilcke, M N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine US Patent US10173988 Publication Date 1/8/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NADPH oxidase 4 |
|---|
| Name: | NADPH oxidase 4 |
|---|
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66954.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_792879 |
|---|
| Residue: | 578 |
|---|
| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
|
|
|
|---|
| BDBM318936 |
|---|
| n/a |
|---|
| Name | BDBM318936 |
|---|
| Synonyms: | US10173988, Compound A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29N7O |
|---|
| Mol. Mass. | 419.5227 |
|---|
| SMILES | COc1cccc(c1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
