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TargetSolute carrier family 22 member 12
LigandBDBM318941
Substrate/Competitorn/a
Meas. Tech.HEK-URAT1 assay
IC50 2060±n/a nM
Citation Endo TKobayashi KTanaka HSaito DHirano MEndou HAnzai N URAT1 inhibitor US Patent  US10173990 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 22 member 12
Name:Solute carrier family 22 member 12
Synonyms:OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | SLC22A12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:Enzyme
Mol. Mass.:59638.65
Organism:Homo sapiens (Human)
Description:Q96S37
Residue:553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM318941
n/a
NameBDBM318941
Synonyms:2-[(4′-Cyano-(1,1′-binaphthalene)-2-yl]oxy]-2-methylpropanoic acid | US10173990, Example 2
TypeSmall organic molecule
Emp. Form.C25H19NO3
Mol. Mass.381.4233
SMILESCC(C)(Oc1ccc2ccccc2c1-c1ccc(C#N)c2ccccc12)C(O)=O |(-3.75,-2.29,;-4.52,-.95,;-5.29,.38,;-3.19,-.18,;-1.85,-.95,;-1.85,-2.49,;-.52,-3.26,;.81,-2.49,;2.15,-3.26,;3.48,-2.49,;3.48,-.95,;2.15,-.18,;.81,-.95,;-.52,-.18,;-.52,1.36,;-1.85,2.13,;-1.85,3.67,;-.52,4.44,;-.52,5.98,;-.52,7.52,;.81,3.67,;2.15,4.44,;3.48,3.67,;3.48,2.13,;2.15,1.36,;.81,2.13,;-5.85,-1.72,;-5.85,-3.26,;-7.19,-.95,)|
Structure
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