| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
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| Ligand | BDBM318947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HEK-URAT1 assay |
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| IC50 | 26.2±n/a nM |
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| Citation |  Endo, T; Kobayashi, K; Tanaka, H; Saito, D; Hirano, M; Endou, H; Anzai, N URAT1 inhibitor US Patent US10173990 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 12 |
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| Name: | Solute carrier family 22 member 12 |
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| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59638.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96S37 |
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| Residue: | 553 |
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| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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| BDBM318947 |
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| n/a |
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| Name | BDBM318947 |
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| Synonyms: | 1-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]cyclopentan-1-carboxylic acid | US10173990, Example 68 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2O2S2 |
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| Mol. Mass. | 380.483 |
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| SMILES | OC(=O)C1(CCCC1)Sc1ccc2cnsc2c1-c1ccc(cc1)C#N |
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| Structure | 
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