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TargetSolute carrier family 22 member 12
LigandBDBM318951
Substrate/Competitorn/a
Meas. Tech.HEK-URAT1 assay
IC50 205±n/a nM
Citation Endo, TKobayashi, KTanaka, HSaito, DHirano, MEndou, HAnzai, N URAT1 inhibitor US Patent US10173990 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 22 member 12
Name:Solute carrier family 22 member 12
Synonyms:OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:Enzyme
Mol. Mass.:59638.65
Organism:Homo sapiens (Human)
Description:Q96S37
Residue:553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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  Blast E-value cutoff:
BDBM318951
n/a
NameBDBM318951
Synonyms:2-[[7-(3-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]-2-methylpropanoic acid | US10173990, Example 84
TypeSmall organic molecule
Emp. Form.C18H14N2O2S2
Mol. Mass.354.446
SMILESCC(C)(Sc1ccc2cnsc2c1-c1cccc(c1)C#N)C(O)=O
Structure
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