Reaction Details |
| Report a problem with these data |
Target | Endothelial lipase |
---|
Ligand | BDBM319007 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biological Activity |
---|
IC50 | 1.000±n/a nM |
---|
Citation | Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US10173991 Publication Date 1/8/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelial lipase |
---|
Name: | Endothelial lipase |
Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
Type: | Protein |
Mol. Mass.: | 56805.62 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5X9 |
Residue: | 500 |
Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
|
|
|
BDBM319007 |
---|
n/a |
---|
Name | BDBM319007 |
Synonyms: | US10173991, Example 48 | benzyl N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (pentane-1- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol-6-yl] phenyl}carbamate |
Type | Small organic molecule |
Emp. Form. | C33H35FN4O6S2 |
Mol. Mass. | 666.783 |
SMILES | CCCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1 |
Structure |
|