Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEndothelial lipase
LigandBDBM319013
Substrate/Competitorn/a
Meas. Tech.Biological Activity
IC50 1.000±n/a nM
Citation Johnson, JAPi, ZQiao, JXKim, SWang, TCJiang, JFinlay, HLloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US10173991 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Endothelial lipase
Name:Endothelial lipase
Synonyms:EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:Protein
Mol. Mass.:56805.62
Organism:Homo sapiens (Human)
Description:Q9Y5X9
Residue:500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM319013
n/a
NameBDBM319013
Synonyms:US10173991, Example 54 | benzyl N-(4-{2- [cyclohexyl- methanesulfonyl ({[(cyclopropyl- carbamoyl)methyl] carbamoyl}) methyl]-5-fluoro- 1,3-benzothiazol- 6-yl}phenyl) carbamate
TypeSmall organic molecule
Emp. Form.C35H37FN4O6S2
Mol. Mass.692.82
SMILESFc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CC1CCCCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: