| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelial lipase |
|---|
| Ligand | BDBM319205 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Activity |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US10173991 Publication Date 1/8/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelial lipase |
|---|
| Name: | Endothelial lipase |
|---|
| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56805.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5X9 |
|---|
| Residue: | 500 |
|---|
| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
|
|
|
|---|
| BDBM319205 |
|---|
| n/a |
|---|
| Name | BDBM319205 |
|---|
| Synonyms: | N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6-(2- methyl-1,3- benzothiazol-5- yl)-1,3- benzothiazol-2- yl]-2- methanesulfonyl- acetamide | US10173991, Example 248 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21FN4O4S3 |
|---|
| Mol. Mass. | 532.631 |
|---|
| SMILES | Cc1nc2cc(ccc2s1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(C)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
