| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM319442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Activity |
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| IC50 | 1.000±n/a nM |
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| Citation |  Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US10173991 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM319442 |
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| n/a |
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| Name | BDBM319442 |
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| Synonyms: | N-[(cyclopropyl- carbamoyl) methyl]-2- (dimethyl- sulfamoyl)-2-[4- fluoro-6-(2- methyl-1-oxo-1,2- dihydro- isoquinolin-6-yl)- 1,3-benzothiazol- 2-yl]acetamide | US10173991, Example 493 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26FN5O5S2 |
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| Mol. Mass. | 571.644 |
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| SMILES | CN(C)S(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2c(F)cc(cc2s1)-c1ccc2c(ccn(C)c2=O)c1 |
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| Structure | 
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