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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM319572
Substrate/Competitorn/a
Meas. Tech.IRAK4 Enzymatic DELFIA Assay, Protocol B
IC50 0.800±n/a nM
Citation Lee, KL; Allais, CP; Dehnhardt, CM; Gavrin, LK; Han, S; Hepworth, D; Lee, A; Lovering, FE; Mathias, JP; Owen, DR; Papaioannou, N; Saiah, E; Strohbach, JW; Trzupek, JD; Wright, SW; Zapf, CW Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators US Patent US10174000 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM319572
n/a
NameBDBM319572
Synonyms:1-(((4S,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide | US10174000, Example 24
TypeSmall organic molecule
Emp. Form.C18H18FN3O4
Mol. Mass.359.3516
SMILESCOc1cc2c(OC[C@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O |r|
Structure
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