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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM319580
Substrate/Competitorn/a
Meas. Tech.IRAK4 Enzymatic DELFIA Assay, Protocol B
IC50 4.50±n/a nM
Citation Lee, KLAllais, CPDehnhardt, CMGavrin, LKHan, SHepworth, DLee, ALovering, FEMathias, JPOwen, DRPapaioannou, NSaiah, EStrohbach, JWTrzupek, JDWright, SWZapf, CW Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators US Patent US10174000 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM319580
n/a
NameBDBM319580
Synonyms:5-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-3-methoxy-1,6-naphthyridine-2-carboxamide | US10174000, Example 32
TypeSmall organic molecule
Emp. Form.C17H19FN4O4
Mol. Mass.362.3556
SMILESCC[C@H]1[C@@H](COc2nccc3nc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F |r|
Structure
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