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TargetKetohexokinase
LigandBDBM319584
Substrate/Competitorn/a
Meas. Tech.KHK Assay A
IC50 256±n/a nM
Citation Dowling, MFernando, DFutatsugi, KHuard, KMagee, TVRaymer, BShavnya, ASmith, AThuma, BTsai, ATu, M Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors US Patent US10174007 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Ketohexokinase
Name:Ketohexokinase
Synonyms:Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C
Type:Enzyme Catalytic Domain
Mol. Mass.:32521.64
Organism:Homo sapiens (Human)
Description:n/a
Residue:298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM319584
n/a
NameBDBM319584
Synonyms:US10174007, Example 3 | US10787438, Example 3 | US10988463, Example 3
TypeSmall organic molecule
Emp. Form.C17H21F3N4O2
Mol. Mass.370.3694
SMILESCOC(=O)C[C@H]1[C@@H]2CN(C[C@H]12)c1cc(nc(n1)N1CC[C@@H]1C)C(F)(F)F |r|
Structure
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