| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ketohexokinase |
|---|
| Ligand | BDBM319605 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KHK Assay C |
|---|
| IC50 | 2.60±n/a nM |
|---|
| Citation |  Dowling, M; Fernando, D; Futatsugi, K; Huard, K; Magee, TV; Raymer, B; Shavnya, A; Smith, A; Thuma, B; Tsai, A; Tu, M Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors US Patent US10174007 Publication Date 1/8/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ketohexokinase |
|---|
| Name: | Ketohexokinase |
|---|
| Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 32521.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 298 |
|---|
| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
|
|
|
|---|
| BDBM319605 |
|---|
| n/a |
|---|
| Name | BDBM319605 |
|---|
| Synonyms: | US10174007, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-(1,1-difluoroethyl)-3-fluoro-6-[(2S,3R)-3-hydroxy-2-methylazetidin-1-yl]pyridin-2-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21F3N4O3 |
|---|
| Mol. Mass. | 410.3902 |
|---|
| SMILES | C[C@H]1[C@H](O)CN1c1nc(N2C[C@H]3[C@H](CC(O)=O)[C@H]3C2)c(F)c(c1C#N)C(C)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
