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TargetP2X purinoceptor 2
LigandBDBM319914
Substrate/Competitorn/a
Meas. Tech.Intracellular Calcium Measurement to Assess Antagonist Activity at Human P2X3 and Human P2X2/3 Receptors
IC50 34.0±n/a nM
Citation Davenport, AJBräuer, NFischer, OMRotgeri, ARottmann, ANeagoe, INagel, JGodinho-Coelho, AKlar, J 1,3-thiazol-2-yl substituted benzamides US Patent US10174016 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 2
Name:P2X purinoceptor 2
Synonyms:ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3
Type:Enzyme Catalytic Domain
Mol. Mass.:51765.18
Organism:Homo sapiens (Human)
Description:PurinergicP2X2/3 0 HUMAN::Q9UBL9
Residue:471
Sequence:
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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  Blast E-value cutoff:
BDBM319914
n/a
NameBDBM319914
Synonyms:N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide | US10174016, Example 81 | US10202369, Example 81 | US10472354, Example 81
TypeSmall organic molecule
Emp. Form.C23H23ClFN3O3S
Mol. Mass.475.963
SMILESCC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
Structure
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