Reaction Details |
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Target | P2X purinoceptor 2 |
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Ligand | BDBM320144 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Intracellular Calcium Measurement to Assess Antagonist Activity at Human P2X3 and Human P2X2/3 Receptors |
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IC50 | 35.0±n/a nM |
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Citation | Davenport, AJ; Bräuer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J 1,3-thiazol-2-yl substituted benzamides US Patent US10174016 Publication Date 1/8/2019 |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 2 |
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Name: | P2X purinoceptor 2 |
Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51765.18 |
Organism: | Homo sapiens (Human) |
Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
Residue: | 471 |
Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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BDBM320144 |
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n/a |
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Name | BDBM320144 |
Synonyms: | N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide | US10174016, Example 311 | US10202369, Example 311 | US10472354, Example 314 |
Type | Small organic molecule |
Emp. Form. | C25H28F3N5O2S |
Mol. Mass. | 519.582 |
SMILES | C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1 |r| |
Structure |
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