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TargetPhosphodiesterase
LigandBDBM320726
Substrate/Competitorn/a
Meas. Tech.Lab B PDE2 assay
Ki 0.059±n/a nM
Citation Shen, DDwyer, MPSinz, CJWang, DStachel, SJPaone, DVForster, ABerger, RChen, YQian, YXu, SHu, C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent US10174037 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:PDE2A
Type:Enzyme Catalytic Domain
Mol. Mass.:105104.20
Organism:Macaca mulatta (Rhesus macaque)
Description:n/a
Residue:935
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPPQPCADSLQDALLSLGSVIDISGLQRA
VKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSD
LPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLV
ALRRVQALQQRRPSEAPRAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQ
LKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSI
QLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVI
QHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN
AEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPL
FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGI
SIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYT
PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSH
FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM
ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRG
LPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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  Blast E-value cutoff:
BDBM320726
n/a
NameBDBM320726
Synonyms:(R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (trifluoromethyl)phenyl)-2- methylpropyl)-3- (hydroxymethyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one | US10174037, Example 132 | US10174037, Example 133
TypeSmall organic molecule
Emp. Form.C19H21F4N5O2
Mol. Mass.427.396
SMILESCC(C)C(c1ccc(cc1F)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Structure
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