Reaction Details |
| Report a problem with these data |
Target | Phosphodiesterase |
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Ligand | BDBM320726 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Lab B PDE2 assay |
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Ki | 0.059±n/a nM |
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Citation | Shen, D; Dwyer, MP; Sinz, CJ; Wang, D; Stachel, SJ; Paone, DV; Forster, A; Berger, R; Chen, Y; Qian, Y; Xu, S; Hu, C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent US10174037 Publication Date 1/8/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Phosphodiesterase |
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Name: | Phosphodiesterase |
Synonyms: | PDE2A |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 105104.20 |
Organism: | Macaca mulatta (Rhesus macaque) |
Description: | n/a |
Residue: | 935 |
Sequence: | MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPPQPCADSLQDALLSLGSVIDISGLQRA
VKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSD
LPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLV
ALRRVQALQQRRPSEAPRAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQ
LKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSI
QLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVI
QHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN
AEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPL
FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGI
SIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYT
PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSH
FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM
ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRG
LPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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BDBM320726 |
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n/a |
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Name | BDBM320726 |
Synonyms: | (R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (trifluoromethyl)phenyl)-2- methylpropyl)-3- (hydroxymethyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one | US10174037, Example 132 | US10174037, Example 133 |
Type | Small organic molecule |
Emp. Form. | C19H21F4N5O2 |
Mol. Mass. | 427.396 |
SMILES | CC(C)C(c1ccc(cc1F)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C |
Structure |
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