| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM320732 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Lab B PDE2 assay |
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| Ki | 0.040±n/a nM |
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| Citation |  Shen, D; Dwyer, MP; Sinz, CJ; Wang, D; Stachel, SJ; Paone, DV; Forster, A; Berger, R; Chen, Y; Qian, Y; Xu, S; Hu, C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent US10174037 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | PDE2A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105104.20 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | n/a |
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| Residue: | 935 |
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| Sequence: | MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPPQPCADSLQDALLSLGSVIDISGLQRA
VKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSD
LPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLV
ALRRVQALQQRRPSEAPRAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQ
LKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSI
QLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVI
QHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN
AEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPL
FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGI
SIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYT
PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSH
FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM
ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRG
LPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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| BDBM320732 |
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| n/a |
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| Name | BDBM320732 |
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| Synonyms: | (R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)-2- methylpropyl)-6- (dimethylamino)-3- (hydroxymethyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one | US10174037, Example 138 | US10174037, Example 139 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25F2N5O2 |
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| Mol. Mass. | 405.4416 |
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| SMILES | CC(C)C(c1ccc(cc1)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C |
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| Structure | 
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