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TargetPhosphodiesterase
LigandBDBM320817
Substrate/Competitorn/a
Meas. Tech.Lab B PDE2 assay
Ki 0.063±n/a nM
Citation Shen DDwyer MPSinz CJWang DStachel SJPaone DVForster ABerger RChen YQian YXu SHu C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent  US10174037 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:PDE2A
Type:Enzyme Catalytic Domain
Mol. Mass.:105104.20
Organism:Macaca mulatta (Rhesus macaque)
Description:n/a
Residue:935
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPPQPCADSLQDALLSLGSVIDISGLQRA
VKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSD
LPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLV
ALRRVQALQQRRPSEAPRAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQ
LKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSI
QLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVI
QHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN
AEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPL
FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGI
SIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYT
PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSH
FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM
ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRG
LPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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  Blast E-value cutoff:
BDBM320817
n/a
NameBDBM320817
Synonyms:(R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(trifluoromethyl)phenyl)propyl)-3- (fluoromethyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one | US10174037, Example 222 | US10174037, Example 223
TypeSmall organic molecule
Emp. Form.C18H18F5N5O
Mol. Mass.415.3604
SMILESCCC(c1ccc(c(F)c1)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Structure
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