Reaction Details |
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Target | Collagenase ColG |
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Ligand | BDBM11349 |
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Substrate/Competitor | BDBM11462 |
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Meas. Tech. | Carbonic Anhydrase Enzyme Inhibition Assay |
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Ki | 13±n/a nM |
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Citation | Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem43:3677-87 (2000) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Collagenase ColG |
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Name: | Collagenase ColG |
Synonyms: | 3.4.24.3 | COLG_HATHI | Class I collagenase | Collagenase (ChC) | Collagenase ColG | Gelatinase ColG | Microbial collagenase | class 1 collagenase | colG |
Type: | Enzyme |
Mol. Mass.: | 126246.16 |
Organism: | Clostridium histolyticum |
Description: | Q9S0X0 |
Residue: | 1118 |
Sequence: | MKKNILKILMDSYSKESKIQTVRRVTSVSLLAVYLTMNTSSLVLAKPIENTNDTSIKNVE
KLRNAPNEENSKKVEDSKNDKVEHVKNIEEAKVEQVAPEVKSKSTLRSASIANTNSEKYD
FEYLNGLSYTELTNLIKNIKWNQINGLFNYSTGSQKFFGDKNRVQAIINALQESGRTYTA
NDMKGIETFTEVLRAGFYLGYYNDGLSYLNDRNFQDKCIPAMIAIQKNPNFKLGTAVQDE
VITSLGKLIGNASANAEVVNNCVPVLKQFRENLNQYAPDYVKGTAVNELIKGIEFDFSGA
AYEKDVKTMPWYGKIDPFINELKALGLYGNITSATEWASDVGIYYLSKFGLYSTNRNDIV
QSLEKAVDMYKYGKIAFVAMERITWDYDGIGSNGKKVDHDKFLDDAEKHYLPKTYTFDNG
TFIIRAGDKVSEEKIKRLYWASREVKSQFHRVVGNDKALEVGNADDVLTMKIFNSPEEYK
FNTNINGVSTDNGGLYIEPRGTFYTYERTPQQSIFSLEELFRHEYTHYLQARYLVDGLWG
QGPFYEKNRLTWFDEGTAEFFAGSTRTSGVLPRKSILGYLAKDKVDHRYSLKKTLNSGYD
DSDWMFYNYGFAVAHYLYEKDMPTFIKMNKAILNTDVKSYDEIIKKLSDDANKNTEYQNH
IQELADKYQGAGIPLVSDDYLKDHGYKKASEVYSEISKAASLTNTSVTAEKSQYFNTFTL
RGTYTGETSKGEFKDWDEMSKKLDGTLESLAKNSWSGYKTLTAYFTNYRVTSDNKVQYDV
VFHGVLTDNADISNNKAPIAKVTGPSTGAVGRNIEFSGKDSKDEDGKIVSYDWDFGDGAT
SRGKNSVHAYKKAGTYNVTLKVTDDKGATATESFTIEIKNEDTTTPITKEMEPNDDIKEA
NGPIVEGVTVKGDLNGSDDADTFYFDVKEDGDVTIELPYSGSSNFTWLVYKEGDDQNHIA
SGIDKNNSKVGTFKSTKGRHYVFIYKHDSASNISYSLNIKGLGNEKLKEKENNDSSDKAT
VIPNFNTTMQGSLLGDDSRDYYSFEVKEEGEVNIELDKKDEFGVTWTLHPESNINDRITY
GQVDGNKVSNKVKLRPGKYYLLVYKYSGSGNYELRVNK
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BDBM11349 |
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BDBM11462 |
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Name | BDBM11349 |
Synonyms: | 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-4-methylpentanamide | Hydroxamate 30 |
Type | Small organic molecule |
Emp. Form. | C20H26N2O5S |
Mol. Mass. | 406.496 |
SMILES | COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(CC(C)C)C(=O)NO |
Structure |
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