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TargetCarbonic anhydrase 2
LigandBDBM11396
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
pH7.2±n/a
Temperature277.15±n/a K
IC50 2.25±n/a nM
Citation Chen, HHGross, SLiao, JMcLaughlin, MDean, TSly, WSMay, JA 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Bioorg Med Chem8:957-75 (2000) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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BDBM11396
BDBM10856
NameBDBM11396
Synonyms:1,1-dioxo-2-[2-(propylamino)ethyl]-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride | 2-[2-(Propylamino)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride | 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 4 | Compound 5d
TypeSmall organic molecule
Emp. Form.C11H17N3O4S3
Mol. Mass.351.465
SMILESCCCNCCN1C=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O |c:7|
Structure
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