| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Ligand | BDBM322535 |
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| Substrate/Competitor | n/a |
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| IC50 | <4±n/a nM |
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| Citation |  Bingham, M; Testar, R; Gignoux, C Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers US Patent US10183939 Publication Date 1/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Synonyms: | C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 72984.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 Y340D Y341D |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM322535 |
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| n/a |
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| Name | BDBM322535 |
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| Synonyms: | 5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one | US10183939, Example 13 | USRE49361, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21FN4O3 |
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| Mol. Mass. | 456.4683 |
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| SMILES | Fc1ccc(cc1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 |
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| Structure | 
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