Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM323020 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLAP Binding Assay (Test A) |
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IC50 | 2500±n/a nM |
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Citation | Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM323020 |
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n/a |
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Name | BDBM323020 |
Synonyms: | (1S,2S or 1R,2R)-N-(3-Cyano-1-methyl- 1H-pyrazol-4-yl)-2-[4-(3-methyl-1H- pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 5a | US10183947, Example 5b |
Type | Small organic molecule |
Emp. Form. | C23H24N6O2 |
Mol. Mass. | 416.4757 |
SMILES | Cc1cc([nH]n1)-c1ccc(cc1)C(=O)C1CCCCC1C(=O)Nc1cn(C)nc1C#N |w:19.22,14.15| |
Structure |
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