Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM323032 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLAP Binding Assay (Test A) |
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IC50 | 22.0±n/a nM |
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Citation | Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM323032 |
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n/a |
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Name | BDBM323032 |
Synonyms: | (1R,2R)-N-(5-Methyl-4-oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-2- [4-(5-methyl-1H-pyrazol-3- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 16 | US10508119, Example 16 | US11001589, Example 16 | US11691978, Example 16 |
Type | Small organic molecule |
Emp. Form. | C25H28N6O3 |
Mol. Mass. | 460.5282 |
SMILES | CN1CCn2ncc(NC(=O)[C@@H]3CCCC[C@H]3C(=O)c3ccc(cc3)-c3cc(C)[nH]n3)c2C1=O |r| |
Structure |
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