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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM323041
Substrate/Competitorn/a
Meas. Tech.FLAP Binding Assay (Test A)
IC50 8.10±n/a nM
Citation Broddefalk, JOEmtenäs, HFGranberg, KLLemurell, MAPettersen, DTPlowright, ATUlander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM323041
n/a
NameBDBM323041
Synonyms:(1R,2R)-N-(4-Oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-2- [4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 24 | US10508119, Example 24 | US11001589, Example 24 | US11691978, Example 24
TypeSmall organic molecule
Emp. Form.C23H24N6O3
Mol. Mass.432.4751
SMILESO=C(Nc1cnn2CCNC(=O)c12)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1ccn[nH]1 |r|
Structure
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