| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase-activating protein |
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| Ligand | BDBM323066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLAP Binding Assay (Test A) |
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| IC50 | 44.0±n/a nM |
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| Citation |  Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase-activating protein |
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| Name: | Arachidonate 5-lipoxygenase-activating protein |
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| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 18159.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20292 |
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| Residue: | 161 |
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| Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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| BDBM323066 |
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| n/a |
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| Name | BDBM323066 |
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| Synonyms: | (1R,2R and 1S,1S)-N-(4-Cyano-3-methyl- 1,2-thiazol-5-yl)-2-[4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 49 | US10508119, Example 49 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O2S |
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| Mol. Mass. | 419.499 |
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| SMILES | Cc1nsc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)c1C#N |w:8.7,13.14| |
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| Structure | 
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