Reaction Details |
| Report a problem with these data |
Target | Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
---|
Ligand | BDBM323134 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Radioactive Binding Assay |
---|
IC50 | 3.00±n/a nM |
---|
Citation | Bock, MG; Moebitz, H; Panigrahi, SK; Poddutoori, R; Samajdar, S Compounds and compositions as inhibitors of MEK US Patent US9629836 Publication Date 4/25/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
---|
Name: | Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
Synonyms: | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1)(K97R) | MAP2K1 | MEK1 | MEK1 (K97R) | MP2K1_HUMAN | PRKMK1 |
Type: | n/a |
Mol. Mass.: | 43467.04 |
Organism: | Homo sapiens (Human) |
Description: | Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation. |
Residue: | 393 |
Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
|
|
|
BDBM323134 |
---|
n/a |
---|
Name | BDBM323134 |
Synonyms: | US10011599, Example 58 | US9629836, 58 |
Type | Small organic molecule |
Emp. Form. | C29H24ClF2N7O |
Mol. Mass. | 559.997 |
SMILES | Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(CC#N)CC1F)-c1ccc(Oc2nccc(C)n2)cc1Cl |r| |
Structure |
|