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TargetDual specificity mitogen-activated protein kinase kinase 1 [K97R]
LigandBDBM323134
Substrate/Competitorn/a
Meas. Tech.Radioactive Binding Assay
IC50 3.00±n/a nM
Citation Bock, MGMoebitz, HPanigrahi, SKPoddutoori, RSamajdar, S Compounds and compositions as inhibitors of MEK US Patent US9629836 Publication Date 4/25/2017
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 1 [K97R]
Name:Dual specificity mitogen-activated protein kinase kinase 1 [K97R]
Synonyms:Dual specificity mitogen-activated protein kinase kinase 1 (MEK1)(K97R) | MAP2K1 | MEK1 | MEK1 (K97R) | MP2K1_HUMAN | PRKMK1
Type:n/a
Mol. Mass.:43467.04
Organism:Homo sapiens (Human)
Description:Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation.
Residue:393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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  Blast E-value cutoff:
BDBM323134
n/a
NameBDBM323134
Synonyms:US10011599, Example 58 | US9629836, 58
TypeSmall organic molecule
Emp. Form.C29H24ClF2N7O
Mol. Mass.559.997
SMILESCc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(CC#N)CC1F)-c1ccc(Oc2nccc(C)n2)cc1Cl |r|
Structure
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