| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
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| Ligand | BDBM200461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioactive Binding Assay |
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| IC50 | 2.60±n/a nM |
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| Citation |  Bock, MG; Moebitz, H; Panigrahi, SK; Poddutoori, R; Samajdar, S Compounds and compositions as inhibitors of MEK US Patent US9629836 Publication Date 4/25/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 1 [K97R] |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1)(K97R) | MAP2K1 | MEK1 | MEK1 (K97R) | MP2K1_HUMAN | PRKMK1 |
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| Type: | n/a |
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| Mol. Mass.: | 43467.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation. |
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| Residue: | 393 |
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| Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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| BDBM200461 |
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| n/a |
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| Name | BDBM200461 |
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| Synonyms: | US10011599, Example 90 | US9227969, 90 | US9629836, 90 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26F2N6O3 |
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| Mol. Mass. | 544.5519 |
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| SMILES | Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(C[C@@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1C |r| |
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| Structure | 
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