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TargetSerine/threonine-protein kinase Chk1
LigandBDBM323098
Substrate/Competitorn/a
Meas. Tech.Kinase Inhibition Asssay
IC50 0.140±n/a nM
Citation Boyle, RGBoyce, RJ Pharmaceutically active pyrazine derivatives US Patent US9630931 Publication Date 4/25/2017
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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  Blast E-value cutoff:
BDBM323098
n/a
NameBDBM323098
Synonyms:US9630931, Example 3
TypeSmall organic molecule
Emp. Form.C20H24ClN7O3
Mol. Mass.445.903
SMILESCOc1cc(CCNC[C@@H]2CNCCO2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N |r|
Structure
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