| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM11507 |
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| Substrate/Competitor | BDBM11156 |
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| Meas. Tech. | Dipeptidyl Peptidase Inhibition Assay |
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| IC50 | 330±n/a nM |
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| Citation |  Xu, J; Wei, L; Mathvink, R; He, J; Park, YJ; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Wu, JK; Thornberry, NA; Weber, AE Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett15:2533-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
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| Type: | Protein |
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| Mol. Mass.: | 54339.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHL4 |
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| Residue: | 492 |
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| Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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| BDBM11507 |
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| BDBM11156 |
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| Name | BDBM11507 |
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| Synonyms: | (2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methoxyphenyl)phenyl]-1-oxobutan-2-aminium; 2,2,2-trifluoroacetate | 3-(S)-fluoropyrrolidide 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26FN2O2 |
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| Mol. Mass. | 357.4412 |
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| SMILES | COc1ccc(cc1)-c1ccc(cc1)[C@H](C)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1 |r| |
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| Structure | 
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