Reaction Details |
| Report a problem with these data |
Target | Dual specificity protein kinase TTK |
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Ligand | BDBM230975 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Measurement of Inhibition of MPS1 Kinase |
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IC50 | 2.00±n/a nM |
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Citation | Hoelder, S; Blagg, J; Cheung, KJ; Atrash, B; Sheldrake, P Pharmacologically active compounds US Patent US10188642 Publication Date 1/29/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase TTK |
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Name: | Dual specificity protein kinase TTK |
Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
Type: | Protein |
Mol. Mass.: | 97086.79 |
Organism: | Homo sapiens (Human) |
Description: | P33981 |
Residue: | 857 |
Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
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BDBM230975 |
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n/a |
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Name | BDBM230975 |
Synonyms: | US10188642, Example 102 | US9334286, 102 |
Type | Small organic molecule |
Emp. Form. | C27H29N7O2 |
Mol. Mass. | 483.5649 |
SMILES | COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1C |
Structure |
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