| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM324255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Inhibitory Activity Against Factor IXa |
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| IC50 | 1.80±n/a nM |
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| Citation |  Zhang, T; Chen, Y; Guo, L; Hruza, A; Jian, T; Li, B; Meng, D; Parker, DL; Sherer, EC; Wood, HB; Sakurada, I Factor IXa inhibitors US Patent US10189819 Publication Date 1/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM324255 |
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| n/a |
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| Name | BDBM324255 |
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| Synonyms: | US10189819, Example 109 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21ClF2N6O3 |
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| Mol. Mass. | 550.944 |
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| SMILES | Cc1ccc(F)c2nc([nH]c(=O)c12)[C@@H](CNC(=O)c1ccc(cc1Cl)-n1cnn(C)c1=O)c1cccc(F)c1 |r| |
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| Structure | 
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