Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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Ligand | BDBM186323 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Raf IC50 Assay |
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Temperature | 298.15±n/a K |
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IC50 | 1600±n/a nM |
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Comments | extracted |
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Citation | Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017 |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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Name: | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
Synonyms: | C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN |
Type: | n/a |
Mol. Mass.: | 38958.87 |
Organism: | Homo sapiens (Human) |
Description: | PV3805, from Invitrogen |
Residue: | 343 |
Sequence: | SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM186323 |
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n/a |
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Name | BDBM186323 |
Synonyms: | US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl) oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)-3-(3-(trifluoromethyl) phenyl)urea | US9670203, Compound 1.31 | US9670203, Compound 1.55 |
Type | Small organic molecule |
Emp. Form. | C25H19F3N4O4 |
Mol. Mass. | 496.438 |
SMILES | FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1 |r| |
Structure |
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