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TargetRAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
LigandBDBM186323
Substrate/Competitorn/a
Meas. Tech.Raf IC50 Assay
Temperature298.15±n/a K
IC50 1600±n/a nM
Commentsextracted
Citation Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Name:RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:n/a
Mol. Mass.:38958.87
Organism:Homo sapiens (Human)
Description:PV3805, from Invitrogen
Residue:343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM186323
n/a
NameBDBM186323
Synonyms:US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl) oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)-3-(3-(trifluoromethyl) phenyl)urea | US9670203, Compound 1.31 | US9670203, Compound 1.55
TypeSmall organic molecule
Emp. Form.C25H19F3N4O4
Mol. Mass.496.438
SMILESFC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1 |r|
Structure
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