Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
LigandBDBM186817
Substrate/Competitorn/a
Meas. Tech.Raf IC50 Assay
Temperature298.15±n/a K
IC50 1600±n/a nM
Commentsextracted
Citation Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Name:RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:n/a
Mol. Mass.:38958.87
Organism:Homo sapiens (Human)
Description:PV3805, from Invitrogen
Residue:343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM186817
n/a
NameBDBM186817
Synonyms:US9670203, Compound 1.9
TypeSmall organic molecule
Emp. Form.C25H18ClF3N4O4
Mol. Mass.530.883
SMILESFC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: