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TargetC-Raf (Y340D/Y341D)
LigandBDBM186828
Substrate/Competitorn/a
Meas. Tech.Raf IC50 Assay
Temperature298.15±n/a K
IC50 2700±n/a nM
Commentsextracted
Citation Zhou CZhang G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017  Article
More Info.:Get all data from this article,  Assay Method
 
C-Raf (Y340D/Y341D)
Name:C-Raf (Y340D/Y341D)
Synonyms:n/a
Type:n/a
Mol. Mass.:38958.87
Organism:Homo sapiens (Human)
Description:PV3805, from Invitrogen
Residue:343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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  Blast E-value cutoff:
BDBM186828
n/a
NameBDBM186828
Synonyms:US9670203, Compound 1.20
TypeSmall organic molecule
Emp. Form.C25H18F4N4O4
Mol. Mass.514.4284
SMILESFc1cc(ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)C(F)(F)F |r|
Structure
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