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TargetSerine/threonine-protein kinase B-raf [416-766,V600E]
LigandBDBM187117
Substrate/Competitorn/a
Meas. Tech.Raf IC50 Assay
Temperature298.15±n/a K
IC50 7700±n/a nM
Commentsextracted
Citation Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase B-raf [416-766,V600E]
Name:Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:n/a
Mol. Mass.:39690.71
Organism:Homo sapiens (Human)
Description:PV3849, from Invitrogen
Residue:351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGK
WHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGS
SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF
GLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP
YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE
LLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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  Blast E-value cutoff:
BDBM187117
n/a
NameBDBM187117
Synonyms:US9670203, Compound 1.32
TypeSmall organic molecule
Emp. Form.C25H18F4N4O4
Mol. Mass.514.4284
SMILESFc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F |r|
Structure
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