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TargetSerine/threonine-protein kinase B-raf [416-766,V600E]
LigandBDBM189824
Substrate/Competitorn/a
Meas. Tech.Raf IC50 Assay
Temperature298.15±n/a K
IC50 1400±n/a nM
Commentsextracted
Citation Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase B-raf [416-766,V600E]
Name:Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:n/a
Mol. Mass.:39690.71
Organism:Homo sapiens (Human)
Description:PV3849, from Invitrogen
Residue:351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGK
WHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGS
SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF
GLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP
YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE
LLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM189824
n/a
NameBDBM189824
Synonyms:US9670203, Compound 1.52
TypeSmall organic molecule
Emp. Form.C25H28N4O4
Mol. Mass.448.5142
SMILESO=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCCCC1 |r|
Structure
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