Reaction Details |
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Target | Serine/threonine-protein kinase B-raf [416-766,V600E] |
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Ligand | BDBM190870 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Raf IC50 Assay |
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Temperature | 298.15±n/a K |
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IC50 | 13000±n/a nM |
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Comments | extracted |
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Citation | Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf [416-766,V600E] |
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Name: | Serine/threonine-protein kinase B-raf [416-766,V600E] |
Synonyms: | B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 |
Type: | n/a |
Mol. Mass.: | 39690.71 |
Organism: | Homo sapiens (Human) |
Description: | PV3849, from Invitrogen |
Residue: | 351 |
Sequence: | LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGK
WHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGS
SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF
GLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP
YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE
LLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM190870 |
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n/a |
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Name | BDBM190870 |
Synonyms: | US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)-3-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1, 8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)urea |
Type | Small organic molecule |
Emp. Form. | C32H33F3N6O4 |
Mol. Mass. | 622.6374 |
SMILES | CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1 |r| |
Structure |
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