| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Ligand | BDBM190870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Raf IC50 Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 840±n/a nM |
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| Comments | extracted |
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| Citation |  Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Synonyms: | C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 38958.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PV3805, from Invitrogen |
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| Residue: | 343 |
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| Sequence: | SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM190870 |
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| n/a |
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| Name | BDBM190870 |
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| Synonyms: | US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)-3-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1, 8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)urea |
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| Type | Small organic molecule |
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| Emp. Form. | C32H33F3N6O4 |
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| Mol. Mass. | 622.6374 |
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| SMILES | CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1 |r| |
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| Structure | 
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