| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Ligand | BDBM50396483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Raf IC50 Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 31000±n/a nM |
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| Comments | extracted |
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| Citation |  Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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| Synonyms: | C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 38958.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PV3805, from Invitrogen |
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| Residue: | 343 |
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| Sequence: | SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50396483 |
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| n/a |
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| Name | BDBM50396483 |
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| Synonyms: | PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18ClF2N3O3S |
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| Mol. Mass. | 489.922 |
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| SMILES | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F |
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| Structure | 
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