Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 | ||
Ligand | BDBM324562 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | JAK Enzyme Assays | ||
Ki | 0.400±n/a nM | ||
Citation | Cheng, Y; Hua, R; Kellar, T; Li, W; Gibbons, P; Zak, ME Therapeutic compounds, compositions and methods of use thereof US Patent US10189836 Publication Date 1/29/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
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BDBM324562 | |||
n/a | |||
Name | BDBM324562 | ||
Synonyms: | 1-(4-methylpiperazin-1- yl)-2-[4-[[8-[8-(3- (trifluoromethyl)- cyclobutanecarbonyl]-3,8- diazabicyclo[3.2.1]octan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]propan-1-one | US10189836, Example 125 | US10189836, Example 126 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H37F3N10O2 | ||
Mol. Mass. | 614.6651 | ||
SMILES | CC(C(=O)N1CCN(C)CC1)n1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)C2CC(C2)C(F)(F)F)cn1 |(-1.55,-1.23,;-2.96,-.61,;-4.19,-1.55,;-4,-3.07,;-5.61,-.95,;-5.81,.58,;-7.23,1.17,;-8.45,.24,;-9.87,.83,;-8.26,-1.29,;-6.84,-1.88,;-3.12,.92,;-1.96,1.94,;-2.58,3.35,;-1.8,4.68,;-.26,4.68,;.64,3.44,;2.11,3.92,;3.44,3.15,;4.78,3.92,;4.77,5.46,;3.44,6.23,;2.11,5.46,;.64,5.93,;3.45,1.61,;2.12,.84,;2.12,-.7,;2.89,.63,;4.02,.63,;4.79,-.7,;4.78,.84,;3.45,-1.47,;3.46,-3.01,;2.13,-3.79,;4.79,-3.78,;5.56,-5.11,;6.9,-4.34,;6.13,-3.01,;8.38,-4.74,;9.47,-3.65,;8.78,-6.23,;9.87,-5.14,;-4.11,3.2,;-4.44,1.7,)| | ||
Structure |