| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
|---|
| Ligand | BDBM11578 |
|---|
| Substrate/Competitor | BDBM11561 |
|---|
| Meas. Tech. | Fluorogenic Assay |
|---|
| IC50 | 10±n/a nM |
|---|
| Citation |  Peters, JU; Weber, S; Kritter, S; Weiss, P; Wallier, A; Boehringer, M; Hennig, M; Kuhn, B; Loeffler, BM Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents. Bioorg Med Chem Lett14:1491-3 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Dipeptidyl peptidase 4 |
|---|
| Name: | Dipeptidyl peptidase 4 |
|---|
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 88271.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27487 |
|---|
| Residue: | 766 |
|---|
| Sequence: | MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
|
|
|
|---|
| BDBM11578 |
|---|
| BDBM11561 |
|---|
| Name | BDBM11578 |
|---|
| Synonyms: | 5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine | Aminomethylpyrimidine 1c | CHEMBL36020 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14Cl2N4 |
|---|
| Mol. Mass. | 345.226 |
|---|
| SMILES | NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
