Reaction Details |
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Target | Carbonic anhydrase 4 |
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Ligand | BDBM11622 |
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Substrate/Competitor | BDBM10856 |
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Meas. Tech. | CA Inhibition Assay |
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Ki | 2.4±n/a nM |
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Citation | Ilies, MA; Vullo, D; Pastorek, J; Scozzafava, A; Ilies, M; Caproiu, MT; Pastorekova, S; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. J Med Chem46:2187-96 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Carbonic anhydrase 4 |
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Name: | Carbonic anhydrase 4 |
Synonyms: | CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4 |
Type: | Enzyme |
Mol. Mass.: | 35152.74 |
Organism: | Bos taurus (bovine) |
Description: | Bovine isozyme, isolated from lung microsomes |
Residue: | 312 |
Sequence: | MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAK
TQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSR
AMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQ
PLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQK
PIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLA
PVLACLTVGFLR
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BDBM11622 |
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BDBM10856 |
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Name | BDBM11622 |
Synonyms: | β-CA inhibitor, 1 | 2-N-(4-amino-3-chlorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide | 5-(4-Amino-3-chlorobenzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide | aminobenzolamide 17c |
Type | Small organic molecule |
Emp. Form. | C8H8ClN5O4S3 |
Mol. Mass. | 369.828 |
SMILES | Nc1ccc(cc1Cl)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O |
Structure |
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