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TargetUbiquitin carboxyl-terminal hydrolase 1
LigandBDBM324906
Substrate/Competitorn/a
Meas. Tech.Ubitquin-Rhodamine 110 Assay for USP1 Activity
IC50<0.002±n/a nM
Citation Buckmelter, AJIoannidis, SFollows, BGustafson, GWang, MCaravella, JAWang, ZFritzen, ELLin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10189841 Publication Date 1/29/2019
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin carboxyl-terminal hydrolase 1
Name:Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:PROTEIN
Mol. Mass.:88191.62
Organism:Homo sapiens (Human)
Description:ChEMBL_104169
Residue:785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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  Blast E-value cutoff:
BDBM324906
n/a
NameBDBM324906
Synonyms:9-(((1r,4r)-4-(3,5- | US10189841, Compound I-112 | US10399980, Compound I-112
TypeSmall organic molecule
Emp. Form.C27H34N6O
Mol. Mass.458.5985
SMILESCC(C)c1ccccc1-c1ncc2n(C)c(=O)n(C[C@H]3CC[C@@H](CC3)n3nc(C)cc3C)c2n1 |r,wU:22.26,wD:19.19,(-8.63,3.74,;-7.3,2.97,;-5.97,3.74,;-7.3,1.43,;-8.63,.66,;-8.63,-.88,;-7.3,-1.65,;-5.97,-.88,;-5.97,.66,;-4.63,1.43,;-4.63,2.97,;-3.3,3.74,;-1.97,2.97,;-.5,3.44,;-.1,4.93,;.4,2.2,;1.94,2.2,;-.5,.95,;-.1,-.54,;1.39,-.94,;1.78,-2.42,;3.27,-2.82,;4.36,-1.73,;3.96,-.25,;2.47,.15,;5.85,-2.13,;6.32,-3.6,;7.86,-3.6,;8.63,-4.93,;8.34,-2.13,;7.09,-1.23,;7.09,.31,;-1.97,1.43,;-3.3,.66,)|
Structure
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