Reaction Details | |||
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Target | Ubiquitin carboxyl-terminal hydrolase 1 | ||
Ligand | BDBM324906 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Ubitquin-Rhodamine 110 Assay for USP1 Activity | ||
IC50 | <0.002±n/a nM | ||
Citation | Buckmelter, AJ; Ioannidis, S; Follows, B; Gustafson, G; Wang, M; Caravella, JA; Wang, Z; Fritzen, EL; Lin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10189841 Publication Date 1/29/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Ubiquitin carboxyl-terminal hydrolase 1 | |||
Name: | Ubiquitin carboxyl-terminal hydrolase 1 | ||
Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP | ||
Type: | PROTEIN | ||
Mol. Mass.: | 88191.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104169 | ||
Residue: | 785 | ||
Sequence: |
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BDBM324906 | |||
n/a | |||
Name | BDBM324906 | ||
Synonyms: | 9-(((1r,4r)-4-(3,5- | US10189841, Compound I-112 | US10399980, Compound I-112 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H34N6O | ||
Mol. Mass. | 458.5985 | ||
SMILES | CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(C[C@H]3CC[C@@H](CC3)n3nc(C)cc3C)c2n1 |r,wU:22.26,wD:19.19,(-8.63,3.74,;-7.3,2.97,;-5.97,3.74,;-7.3,1.43,;-8.63,.66,;-8.63,-.88,;-7.3,-1.65,;-5.97,-.88,;-5.97,.66,;-4.63,1.43,;-4.63,2.97,;-3.3,3.74,;-1.97,2.97,;-.5,3.44,;-.1,4.93,;.4,2.2,;1.94,2.2,;-.5,.95,;-.1,-.54,;1.39,-.94,;1.78,-2.42,;3.27,-2.82,;4.36,-1.73,;3.96,-.25,;2.47,.15,;5.85,-2.13,;6.32,-3.6,;7.86,-3.6,;8.63,-4.93,;8.34,-2.13,;7.09,-1.23,;7.09,.31,;-1.97,1.43,;-3.3,.66,)| | ||
Structure |