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TargetUbiquitin carboxyl-terminal hydrolase 1
LigandBDBM325028
Substrate/Competitorn/a
Meas. Tech.Ubitquin-Rhodamine 110 Assay for USP1 Activity
IC50<0.002±n/a nM
Citation Buckmelter AJIoannidis SFollows BGustafson GWang MCaravella JAWang ZFritzen ELLin J Purinones as ubiquitin-specific protease 1 inhibitors US Patent  US10189841 Publication Date 1/29/2019
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin carboxyl-terminal hydrolase 1
Name:Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:Deubiquitinating enzyme 1 | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:PROTEIN
Mol. Mass.:88191.62
Organism:Homo sapiens (Human)
Description:ChEMBL_104169
Residue:785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM325028
n/a
NameBDBM325028
Synonyms:9-(4-(3-(dimethylamino)propoxy)benzyl)-2-(2- | US10189841, Compound I-234
TypeSmall organic molecule
Emp. Form.C27H33N5O2
Mol. Mass.459.5832
SMILESCC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(OCCCN(C)C)cc3)c2n1
Structure
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