Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 1 |
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Ligand | BDBM325140 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ubitquin-Rhodamine 110 Assay for USP1 Activity |
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IC50 | <0.002±n/a nM |
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Citation | Buckmelter, AJ; Ioannidis, S; Follows, B; Gustafson, G; Wang, M; Caravella, JA; Wang, Z; Fritzen, EL; Lin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10189841 Publication Date 1/29/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 1 |
Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP |
Type: | PROTEIN |
Mol. Mass.: | 88191.62 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104169 |
Residue: | 785 |
Sequence: | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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BDBM325140 |
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n/a |
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Name | BDBM325140 |
Synonyms: | 9-(4-(4-((diethylamino)methyl)-1H-1,2,3-triazol-1- | US10189841, Compound I-346 | US10399980, Compound I-346 |
Type | Small organic molecule |
Emp. Form. | C28H32N8O |
Mol. Mass. | 496.6067 |
SMILES | CCN(CC)Cc1cn(nn1)-c1ccc(Cn2c3nc(ncc3[nH]c2=O)-c2ccccc2C(C)C)cc1 |
Structure |
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