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TargetUbiquitin carboxyl-terminal hydrolase 1
LigandBDBM325140
Substrate/Competitorn/a
Meas. Tech.Ubitquin-Rhodamine 110 Assay for USP1 Activity
IC50<0.002±n/a nM
Citation Buckmelter, AJIoannidis, SFollows, BGustafson, GWang, MCaravella, JAWang, ZFritzen, ELLin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10189841 Publication Date 1/29/2019
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin carboxyl-terminal hydrolase 1
Name:Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:PROTEIN
Mol. Mass.:88191.62
Organism:Homo sapiens (Human)
Description:ChEMBL_104169
Residue:785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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  Blast E-value cutoff:
BDBM325140
n/a
NameBDBM325140
Synonyms:9-(4-(4-((diethylamino)methyl)-1H-1,2,3-triazol-1- | US10189841, Compound I-346 | US10399980, Compound I-346
TypeSmall organic molecule
Emp. Form.C28H32N8O
Mol. Mass.496.6067
SMILESCCN(CC)Cc1cn(nn1)-c1ccc(Cn2c3nc(ncc3[nH]c2=O)-c2ccccc2C(C)C)cc1
Structure
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