| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 [8-360] |
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| Ligand | BDBM193776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ERK-2 Enzymatic Assay |
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| pH | 7.3±n/a |
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| IC50 | 0.90±n/a nM |
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| Comments | extracted |
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| Citation |  Blake, JF; Cook, A; Gaudino, J; Gunawardana, IW; Hicken, EJ; Hunt, KW; Lyon, M; Metcalf, AT; Mohr, PJ; Moreno, DA; Newhouse, B; Ren, L; Schwarz, J; Chen, H; Gazzard, L; Schmidt, J; Do, S Serine/threonine kinase inhibitors US Patent US9670208 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Mitogen-activated protein kinase 1 [8-360] |
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| Name: | Mitogen-activated protein kinase 1 [8-360] |
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| Synonyms: | ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2 |
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| Type: | n/a |
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| Mol. Mass.: | 40835.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 aa 8-360 |
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| Residue: | 353 |
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| Sequence: | GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR
TLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHIC
YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP
SQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQA
LAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM193776 |
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| n/a |
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| Name | BDBM193776 |
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| Synonyms: | US9670208, Example 403 4-(3-(3-fluoro-4-methoxybenzyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23FN6O2 |
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| Mol. Mass. | 434.4661 |
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| SMILES | COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F |
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| Structure | 
|
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