| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM327040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 0.100±n/a nM |
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| Citation |  Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent US9662339 Publication Date 5/30/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
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| Type: | Hydrolase; metalloprotease |
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| Mol. Mass.: | 69280.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant LTA4H. |
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| Residue: | 611 |
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| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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|
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| BDBM327040 |
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| n/a |
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| Name | BDBM327040 |
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| Synonyms: | 4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyridin-3-yl]benzyl}piperidin-4- yl)butanoic acid | US9662339, 151 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N2O4 |
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| Mol. Mass. | 396.4794 |
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| SMILES | OC(=O)CCCC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| |
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| Structure | 
|
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