| Reaction Details |
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 | Report a problem with these data |
| Target | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
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| Ligand | BDBM65495 |
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| Substrate/Competitor | BDBM65498 |
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| Meas. Tech. | NAD glycohydrolase assay |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 88000±8000 nM |
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| Citation |  Muller-Steffner, H; Jacques, SA; Kuhn, I; Schultz, MD; Botta, D; Osswald, P; Maechling, C; Lund, FE; Kellenberger, E Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal. ACS Chem Biol12:1787-1795 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
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| Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
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| Synonyms: | C-His6-SmNACE |
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| Type: | Protein |
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| Mol. Mass.: | 35588.81 |
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| Organism: | Schistosoma mansoni |
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| Description: | Q32TF5 6 His tagged |
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| Residue: | 309 |
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| Sequence: | MMNVILFLTLSNIFVFNSAQHQINLLSEIVQSRCTQWKVEHGATNISCSEIWNSFESILL
STHTKSACVMKSGLFDDFVYQLFELEQQQQQRHHTIQTEQYFHSQVMNIIRGMCKRLGVC
RSLETTFPGYLFDELNWCNGSLTGNTKYGTVCGCDYKSNVVHAFWQSASAEYARRASGNI
FVVLNGSVKAPFNENKTFGKIELPLLKHPRVQQLTVKLVHSLEDVNNRQTCESWSLQELA
NKLNSVHIPFRCIDDPLEFRHYQCIENPGKQLCQFSASTRSNVETLLILFPLVICLTFYT
SMNHHHHHH
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| BDBM65495 |
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| BDBM65498 |
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| Name | BDBM65495 |
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| Synonyms: | SmNACE inhibitor, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N2O4 |
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| Mol. Mass. | 260.2454 |
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| SMILES | Cc1occc1C(=O)N\N=C\c1ccc(O)c(O)c1 |
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| Structure | 
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