Reaction Details |
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Target | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
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Ligand | BDBM65496 |
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Substrate/Competitor | BDBM65498 |
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Meas. Tech. | NAD glycohydrolase assay |
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pH | 7.4±0 |
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Temperature | 310.15±0 K |
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IC50 | 33±5 nM |
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Citation | Muller-Steffner, H; Jacques, SA; Kuhn, I; Schultz, MD; Botta, D; Osswald, P; Maechling, C; Lund, FE; Kellenberger, E Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal. ACS Chem Biol12:1787-1795 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
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Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [1-303] |
Synonyms: | C-His6-SmNACE |
Type: | Protein |
Mol. Mass.: | 35588.81 |
Organism: | Schistosoma mansoni |
Description: | Q32TF5 6 His tagged |
Residue: | 309 |
Sequence: | MMNVILFLTLSNIFVFNSAQHQINLLSEIVQSRCTQWKVEHGATNISCSEIWNSFESILL
STHTKSACVMKSGLFDDFVYQLFELEQQQQQRHHTIQTEQYFHSQVMNIIRGMCKRLGVC
RSLETTFPGYLFDELNWCNGSLTGNTKYGTVCGCDYKSNVVHAFWQSASAEYARRASGNI
FVVLNGSVKAPFNENKTFGKIELPLLKHPRVQQLTVKLVHSLEDVNNRQTCESWSLQELA
NKLNSVHIPFRCIDDPLEFRHYQCIENPGKQLCQFSASTRSNVETLLILFPLVICLTFYT
SMNHHHHHH
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BDBM65496 |
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BDBM65498 |
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Name | BDBM65496 |
Synonyms: | SmNACE inhibitor, 2 |
Type | Small organic molecule |
Emp. Form. | C13H11ClN2O3 |
Mol. Mass. | 278.691 |
SMILES | Cc1occc1C(=O)N\N=C\c1cc(Cl)ccc1O |
Structure |
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