Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetE2 ubiquitin-conjugating enzyme E1
LigandBDBM329873
Substrate/Competitorn/a
Meas. Tech.HTRF Assay
IC50<10±n/a nM
Citation Afroze RBharathan ITCiavarri JPFleming PEGaulin JLGirard MLangston SPSoucy FWong TYe Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
E2 ubiquitin-conjugating enzyme E1
Name:E2 ubiquitin-conjugating enzyme E1
Synonyms:n/a
Type:n/a
Mol. Mass.:21408.98
Organism:Homo sapiens (Human)
Description:P51965
Residue:193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM329873
n/a
NameBDBM329873
Synonyms:(rac)-((1R,2R,3S,4R)-4-(2-(5-fluorobenzo[b]thiophen-3-yl)pyrazolo[1,5-a]pyrimidin- | US10202389, Compound I-081 | US9663525, Compound I-081 | US9796725, Compound I-081
TypeSmall organic molecule
Emp. Form.C20H20FN5O5S2
Mol. Mass.493.532
SMILESNS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2csc3ccc(F)cc23)[C@H](O)[C@@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: