| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin-conjugating enzyme E2 E1 |
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| Ligand | BDBM329877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US9663525 Publication Date 5/30/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin-conjugating enzyme E2 E1 |
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| Name: | Ubiquitin-conjugating enzyme E2 E1 |
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| Synonyms: | E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1 |
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| Type: | n/a |
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| Mol. Mass.: | 21408.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51965 |
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| Residue: | 193 |
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| Sequence: | MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
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| BDBM329877 |
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| n/a |
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| Name | BDBM329877 |
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| Synonyms: | (rac)-((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(9-oxo-9H-fluoren-2-yl)pyrazolo[1,5- | US10202389, Compound I-085 | US9663525, Compound I-085 | US9796725, Compound I-085 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N5O6S |
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| Mol. Mass. | 521.545 |
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| SMILES | NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2ccc3-c4ccccc4C(=O)c3c2)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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